Calcium, Magnesium, Zinc & Vitamin D Supplement | 365 Vegetarian Tablets | 6 Month Supply of Nu U Nutrition Osteo Supplement

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Razzaque M.S. The dualistic role of vitamin D in vascular calcifications. Kidney Int. 2011; 79:708–714. [ PMC free article] [ PubMed] [ Google Scholar]

Vitabiotics’ nutritional experts have formulated Osteocare Original with vitamin D3 derived from a natural vegan plant source (Algal). Hossain S., Beydoun M.A., Beydoun H.A., Chen X., Zonderman A.B., Wood R.J. Vitamin D and breast cancer: a systematic review and meta-analysis of observational studies. Clin Nutr ESPEN. 2019; 30:170–184. [ PMC free article] [ PubMed] [ Google Scholar] To reach these amounts, you would need to take 2–3 calcium-magnesium-zinc supplements over the course of the day. Wan L.Y., Zhang Y.Q., Chen M.D., Liu C.B., Wu J.F. Relationship of structure and function of DNA-binding domain in vitamin D receptor. Molecules. 2015; 20:12389–12399. [ PMC free article] [ PubMed] [ Google Scholar] Holland & Barrett Vegan Calcium, Magnesium, Zinc and Vitamin D contains four proven vitamins and minerals to help support normal bone and muscle function. These tablets support your plant-based diet with the vitamins and nutrients your body needs to stay healthy.Leon O., Roth M. Zinc fingers: DNA binding and protein-protein interactions. Biol. Res. 2000; 33:21–30. [ PubMed] [ Google Scholar] If you experience any of these symptoms, consider lowering your dosage or consulting your healthcare provider.

Cui A, Zhang T, Xiao P, Fan Z, Wang H, Zhuang Y. Global and regional prevalence of vitamin D deficiency in population-based studies from 2000 to 2022: A pooled analysis of 7.9 million participants. Front Nutr. 2023;10:1070808. doi:10.3389/fnut.2023.1070808 King J.C., Brown K.H., Gibson R.S., Krebs N.F., Lowe N.M., Siekmann J.H., Raiten D.J. Biomarkers of nutrition for development (BOND)-Zinc review. J. Nutr. 2015; 146:858s–885s. [ PMC free article] [ PubMed] [ Google Scholar] Razzaque M.S. COVID-19 pandemic: can maintaining optimal zinc balance enhance host resistance? Tohoku J. Exp. Med. 2020; 251:175–181. [ PubMed] [ Google Scholar]This Original formula is also available in a chewable tablet for those who have difficulty with swallowing tablets. Osteocare Chewable provides the same levels of calcium, magnesium and zinc which contribute to the maintenance of normal bone health. Getting enough calcium is especially important for men and women over 50, during pregnancy and breast-feeding, as well as during and after the menopause. Additional demands associated with pregnancy and fetal growth, pose pregnant women at more risk for multiple nutrient deficiencies [ 44]. The results of current study revealed a decreasing trend in newborns’ weight and the rate of macrosomia in the magnesium-zinc-calcium-vitamin D co-supplemented group compared to the placebo group. Following supplementation, the difference between birth weights was large and non-significant between intervention groups (3089.8 vs. 3346.3, P=0.05). This result has been presented as mean values, however when we assessed data of birth weight individually we did not see any birth weight below normal value. On the other hand, the reduction in macrosomia rate was one of the goals of this study. Overall, based on current findings we did not consider these reductions as negative effects. Same research group has already shown that magnesium supplementation might decrease the incidence of newborn hyperbilirubinemia and newborn hospitalization and was less associated with macrosomia [ 10]. Looking at the effect of zinc on pregnancy outcomes, the results are inconclusive, which might be related to high incidence of zinc deficiency in pregnancy and low doses of supplementation are usually used in different trials [ 45, 46]. The combination of vitamin D and calcium has been shown significant reduction in the rate of macrosomia and caesarean section in women with GDM [ 12]. The inconclusive results in the current trial, as a multi-nutrients supplementation approach might be related to the following parameters; supplementation strategies might be beneficial when a deficiency is observed, maternal weight gain during pregnancy is of major importance and is affected by different factors like woman’s age, environmental conditions, diet, socioeconomic status and psychological parameters, higher doses of nutrients might be required to see any effect on pregnancy outcomes [ 47]. Akimbekov N.S., Digel I., Sherelkhan D.K., Lutfor A.B., Razzaque M.S. Vitamin D and the host-gut microbiome: a brief overview. Acta Histochem. Cytoc. 2020; 53:33–42. [ PMC free article] [ PubMed] [ Google Scholar] Lee S.J., Lee E.Y., Lee J.H., Kim J.E., Kim K.J., Rhee Y., Kim H.C., Youm Y., Kim C.O. Associations of serum 25-hydroxyvitamin D with metabolic syndrome and its components in elderly men and women: the Korean Urban Rural Elderly cohort study. BMC Geriatr. 2019; 19:102. [ PMC free article] [ PubMed] [ Google Scholar]