Beet It Organic concentrated beetroot shot (Pack of 15 x 70ml)

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Hezel M, Peleli M, Liu M, Zollbrecht C, Jensen BL, Checa A, et al. Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation. Free Radic Biol Med. 2016;99:87–98. Dejam A, Hunter CJ, Gladwin MT. Effects of dietary nitrate on blood pressure. N Engl J Med. 2007;356(15):1590 author reply. Fermented beetroot juice can be formulated by spontaneous lactic acid fermentation or by use of starter cultures, enriching betalain content in a probiotic product used to supplement healthy men [ 20, 21, 22, 23, 24]. Beetroot-enriched bread were obtained by replacing 50% of total dough weight with white or red beetroot before baking, developing a well-accepted product, which is already being marketed [ 25, 26]. An animal study on the blood-glucose-lowering effect of beetroot juice extended our knowledge in an STZ (Streptozotocin) - induced diabetic rat model. In this study, animals have been treated with either 400 mg/ kg p.o. (orally) Ethanolic Extract of Beetroot Juice or 5 mg/ Kg p.o. Glibenclamide. It was implied that the effect of Glibenclamide on TG and cholesterol level was comparable with that in EEBT- treated animals. In fact, administration of EEBT potentially reduced the serum levels of cholesterol and TG in comparison to diabetic control rats, which is hypothesized to be regarding a long exposure (21 days) to EEBT solution [ 59].

Phytochemicals give plants their color and flavor. They also stimulate the immune system, minimize inflammation, and reduce oxidative stress.NO 3 contributes as one of the most important inorganic compounds within beetroot, the content of which is reported to vary 10-fold between single varieties [ 1]. NO 3 concentration was said to be within a range of 388 ± 19.9 to 3968 ± 252 mg/L among commercial beetroot juice and 393 ± 2.23 to 2721 ± 54.4 mg/L among commercial beetroot powders. Although nitrate is relatively inert, it is yet capable of transforming status into NO 2 through bacterial enzymatic pathways (NO 3 reductase), which subsequently is non- enzymatically decomposed to NO in the oral cavity. The classification of the beetroot organ in terms of NO 3 concentration from highest to lowest is as petiole, leaf, stem, root, tuber, bulb, fruit, and seed, respectively [ 8].

With that said, an animal intervention has investigated the beneficial contribution of either beetroot juice or nutraceutical beetroot juice in the treatment of Gentaciamin-nephrotoxicity- induced rats. It was suggested that beetroot juice with prophylactic perspectives actively supported the renal system to overcome the adverse effects of Gentamicin (GM)'s primary and secondary reactive metabolites, resulting from the toxicant-induced damage. Therefore, consumption of beetroot- based beverages depicted positive implications by increasing the level of Superoxide Dismutase (as a primary antioxidant enzyme), and Catalase (involved in a detoxification procedure), while decreasing NO (with a controversial role in renal system), and oxidative stress, all as renal tissue-specific markers. Similarly, urea and creatinine content have lowered, while the protein profile of beetroot- based beverage accelerated, due to the action of bioactive compounds like betacyanins and betaxanthin [ 75]. The potential interaction of NO 3- rich beetroot juice with phosphodiesterase-5 inhibitors and consequent severe hypotension, is another consideration. Beneficial properties of beetroot can be profoundly affected by medications imposing undesirable interaction with metabolism and the ultimate metabolic pathways of NO 3/ NO 2; as such, the hypotensive effect of orally ingested NO 2 is proposed to be abolished by esomeprazole, a proton pump inhibitor [ 18]. The optimal dose is likely to be 600mg nitrate, equivalent to 2 x 70 ml concentrated beetroot ‘shots’, say University of Exeter researchers, although it has also proved to benefit performance in studies using 300 – 400mg (0.62 mg/kg body weight), equivalent to 500ml beetroot juice or a single 70ml shot. Both acute and chronic loads have an effect. Professor Jones suggests consuming one to two 70ml shots a day for three to five days before competition as well as two to three hours before the race starts (blood NO levels peak 2 – 3 hours after ingestion and approach baseline 12 hours later). Boost your overall dietary nitrate by including more green leafy veg – plus you’ll gain the benefits of other nutrients in these foods too. And the best part of all of this is that research hasn’t found any negative effects. “Well, your pee might be a funny color, but that’s about it,” Antonucci says. “You do a shot, maybe you get 20 to 30 seconds off your time or maybe you don’t; the only thing you’ve lost is the cost of the product.” But runners should try it in training first, Jones warns; “a small minority can suffer gut issues,” he says. (I actually didn’t take a shot the morning of the race because I didn’t want to mess with my stomach.) Several protective strategies have been introduced to hold effective reno-protective implications. The blood pressure lowering effect via the action of Guanylyl Cyclases and cGMP, and subsequent nitrate- nitrite pathway of the facultative bacteria [ 76], a nitrate- mediated reduction of renal oxidative stress via decreasing the NADH oxidase activity and angiotensin II receptor (signals that attenuate angiotensin II-mediated renal arteriolar contraction) [ 77, 78] are of all conclusions drawn to explain the mechanism of action.

Panghal A, Virkar K, Kumar V, Dhull S, Gat Y, Chhikara N. Development of Probiotic Beetroot Drink; 2017. Collected data from a recent study on 30 healthy participants outlined further decreasing trend of blood glucose level by 34.5% following longer-term ingestion of a 10% beetroot juice solution [ 48] within 4 weeks, comparing to the baseline and washout period; whereas such difference was not present within 2 weeks of the interventional phase. With significant assimilation to the hypotensive effect, it can be said that persistent consumption of beetroot juice might be necessary on the maintenance of sustainable impacts of blood glucose and insulin responses [ 49]. Curtis KJ, O'Brien KA, Tanner RJ, Polkey JI, Minnion M, Feelisch M, et al. Acute Dietary Nitrate Supplementation and Exercise Performance in COPD: A Double-Blind, Placebo-Controlled, Randomised Controlled Pilot Study. PloS one. 2015;10(12):e0144504. Guldiken B, Toydemir G, Nur Memis K, Okur S, Boyacioglu D, Capanoglu E. Home-processed red beetroot ( Beta vulgaris L.) products: changes in antioxidant properties and bioaccessibility. Int J Mol Sci. 2016;17(6):858.

Agency CFI. The Biology of Beta vulgaris L. (Sugar Beet). Canadian Food Inspection Agency; Canada: Government of Canada; 2012 [cited 2018]. Available from: http://www.inspection.gc.ca/plants/plants-with-novel-traits/applicants/directive-94-08/biology-documents/beta-vulgaris-l-/eng/1330725373948/1330725437349.Kumar Y. Beetroot: A Super Food. International Journal of Engineering Studies and Technical Approach March 2015;Volume 01, No.3. In contrary to the most common conclusion, emphasizing the exclusive role of NO 3 on the hypotensive effect of beetroot, a recent meta-analysis highlighted the potential NO 3 independent blood pressure lowering effect and postulated a dose-dependent relationship between inorganic NO 3 and its hypotensive effect [ 47]. There are other studies in agreement with this investigation, which have indicated a similar microvascular, vasodilator property following the consumption of NO3- rich beetroot juice, compared to a NO3- depleted placebo, within a period of 24 days [ 28]; hence, it is suggested that bioactive components other than NO3, may mediate dilatory responses among both beverages [ 6]. Altogether, these studies raised evidence in favor of blood glucose lowering effect of beetroot and beetroot juice in particular. It can be implied that beetroot juice is able to effectively lessen the impact of insulin resistance in a drug- comparable manner. Effects of beetroot on microbiome Beetroot-cereal bars present the highest total OA content (9.19 ± 0.71 mg/g) compared to chips (5.34 ± 0.35 mg/g), gel (4.17 ± 0.35 mg/g), and juice (2.84 ± 0.7 mg/g) ( Table 2). Six distinct OAs including citric, ascorbic, malic, fumaric, succinic, and oxalic acids have been quantified in the beetroot-cereal bar, whereas succinic acid and oxalic acid have been found only in beetroot-cereal bars, both derived from the cereals added during bar formulation, while citric acid, ascorbic acid, malic acid, and fumaric acid are found in beets and present in all beet-derivatives. Malic acid and citric acid are the most abundant in beet formulations [ 1] ( Table 2). The overall OA content found in some beetroot product interventions is close to those found in the most dense-dietary sources of OAs, such as kefir (≈12.0 mg/mL) and milk (≈5.0 mg/mL) [ 37].