Canesflor Vaginal Probiotics | Helps Prevent Recurrence of Vaginal Infections such as Thrush | Clinically Proven - 10 Count (Pack of 1)

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women to help maintain vaginal health. Failure of L. rhamnosus GG to be effective, at least in one small study [ 79], emphasizes the strain-specific Austin, M. N., Beigi, R. H., Meyn, L. A. & Hillier, S. L. Microbiologic response to treatment of bacterial vaginosis with topical clindamycin or metronidazole. J. Clin. Microbiol 43, 4492–4497 (2005). appears to involve an ability to adhere to and to populate the vaginal epithelium and mucin layer, to

Curty G., de Carvalho P. S., Soares M. A. (2019). The role of the cervicovaginal microbiome on the genesis and as a biomarker of premalignant cervical intraepithelial neoplasia and invasive cervical cancer. Int. J. Mol. Sci. 21 ( 1), 222. doi: 10.3390/ijms21010222 Cundiff GW, Amundsen CL, Bent AE, et al. The PESSRI study: symptom relief outcomes of a randomized crossover trial of the ring and Gellhorn pessaries. Am J Obstet Gynecol. 2007;196(4):405.e1–405.e8. doi:10.1016/j.ajog.2007.02.018. Patients received metronidazole (500 mg, bid) for 7 days and were randomly assigned to concurrently receive probiotics plus lactoferrin or placebo (n=48). Thus, it is important to follow the dynamics of the vaginal microbiome for at least 6 months following treatment to assess complete clinical cure endpoints 23. Moreover, restoring the vaginal microbiome after antibiotic treatment (e.g., with probiotics or VMT) will assist the recovery of the vaginal environment and complete the whole treatment procedure (Fig. 1). Therefore, evaluation of additional methods for BV treatment and prevention, especially recurrent BV, will be of great value in the clinic. Probiotics Neri, A., Sabah, G. & Samra, Z. Bacterial vaginosis in pregnancy treated with yoghurt. Acta Obstet. Gynecol. Scand. 72, 17–19 (1993).

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Gao W., Weng J., Gao Y., Chen X. (2013). Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study. BMC Infect. Dis. 13, 271. doi: 10.1186/1471-2334-13-271 described in which the vagina is colonized by organisms such as E. coli and enterococci [ 51]. During This study aimed to evaluate the effect of a vaginal probiotic suppository on the vaginal microenvironment among pessary users.

Czaja, C. A., Stapleton, A. E., Yarova-Yarovaya, Y. & Stamm, W. E. Phase I trial of a Lactobacillus crispatus vaginal suppository for prevention of recurrent urinary tract infection in women. Infect. Dis. Obstet. Gynecol. 2007, e35387 (2007). vesicoureteral reflux, L. acidophilus treatment daily was as effective as trimethoprim/sulfamethoxazole in reducingHedges, S. R., Barrientes, F., Desmond, R. A. & Schwebke, J. R. Local and systemic cytokine levels in relation to changes in vaginal flora. J. Infect. Dis. 193, 556–562 (2006). However, the main issue with using antibiotic treatment for BV is the high rate of recurrence within months of treatment 23. Relapse may occur when vaginosis-related bacteria re-colonize and take over the vaginal microbiome. Furthermore, vaginosis-related bacteria that recur after antibiotic treatment, such as Gardnerella vaginalis and Atopobium vaginae, may have higher resistance and become less sensitive to another round of antibiotic treatment 29, 30, 35. Also, orally administered metronidazole and clindamycin disturb the healthy gut microbiome 36, 37, whereas even local usage of antibiotics is a risk factor for vulvovaginal candidiasis 38, 39. Donders G. G. G., Ruban K., Bellen G., Grinceviciene S. (2019). Pharmacotherapy for the treatment of vaginal atrophy. Expert Opin. Pharmacother. 20 ( 7), 821–835. doi: 10.1080/14656566.2019.1574752

Turhan, N. Ö. & Seçki̇n, N. C. Garnerella-associated vaginitis: comparison of three treatment modalities. Turk. J. Med. Sci. 28, 171–174 (1998).Muzny, C. A., Łaniewski, P., Schwebke, J. R. & Herbst-Kralovetz, M. M. Host-vaginal microbiota interactions in the pathogenesis of bacterial vaginosis. Curr. Opin. Infect. Dis. 33, 59–65 (2020). Pan, M., Hidalgo-Cantabrana, C., Goh, Y. J., Sanozky-Dawes, R. & Barrangou, R. Comparative analysis of Lactobacillus gasseri and Lactobacillus crispatus isolated from human urogenital and gastrointestinal tracts. Front. Microbiol. 10, 3146 (2020).